Infex scientists achieve breakthrough with potential new drug for Omicron and new coronavirus strains
Alderley Park, Cheshire, UK – One of the UK’s leading infectious disease biotech companies has announced a breakthrough in laboratory trials of a new drug to treat COVID-19 and new variants of the disease, such as the Omicron variant.
Infex Therapeutics’ COV-X program inhibits a new protease target that is responsible for viral replication across the broad spectrum of SARS-CoV-1, MERS-CoV and SARS-CoV-2. As such, this new approach is unaffected by changes to coronavirus spike protein that is the focus of current concerns about vaccine effectiveness.
Exciting laboratory results at Infex have identified new compounds with a balance of high potency, and encouraging all-round properties including solubility, in-vitro metabolism, plasma-protein binding, and permeability – which are all important factors in achieving oral bioavailability, the key to a successful new drug that could be taken in simple tablet form, rather than by injection.
Encouragingly, leading compounds have shown excellent exposure when dosed orally in mice, paving the way for studies leading to eventual clinical trials in volunteers and COVID-19 patients.
Dr Peter Jackson, Executive Director of Infex commented: “These new compounds work by targeting a key protease essential for viral replication. The inhibitors we are developing will help meet a desperate clinical need for innovative anti-viral agents which are effective in treating breakthrough cases, unvaccinated and high-risk patients, leading to reduced hospitalisation and pressure on healthcare systems, and lower death rates.”
If successfully developed the treatment could form a first line of defence against new strains of SARS-CoV-2 variants – such as Omicron – and may have utility for use in future pandemics, as the protease target is present in different coronavirus strains and species.
Dr Jackson added: “In the event of a new coronavirus threat emerging in the coming years, our new drug could also be administered as a precautionary measure to vulnerable groups including the elderly, immunocompromised people and healthcare workers, potentially greatly reducing the health risks until a bespoke vaccine is produced.”
The next step in the COV-X program will be to fine tune the drug properties and establish safety, before clinical trials can be possible, and the company is looking to secure new Government funding and investment to fast-track the program towards clinical trials.
Dr Peter Jackson further commented: “The UK has been a leader in responding to the COVID-19 vaccine challenge but the impact of coronavirus is far from over and the emergence of Omicron underlines the importance of continued significant investment in programs such as COV-X that will help deliver new treatments that are badly needed.”
The Cov-X program is being delivered in in partnership with the University of Liverpool and the Liverpool School of Tropical Medicine, and supported by the Medicines Discovery Catapult at Alderley Park.
Infex Therapeutics is part of iiCON, the infectious disease innovation consortium led by the Liverpool School of Tropical Medicine and supported by the Strength in Places Fund.
About Infex Therapeutics
Infex acquires, develops and licenses innovative drugs to treat pandemic infections and are creating a portfolio of new therapies to meet the rising burden of critical priority infectious disease. Based at Alderley Park in the North West of England, our work addresses unmet patient needs and will bring new portfolio of drugs into clinical trials to treat patients suffering from life-threatening infections. Our mission is to ensure that all new, novel and needed drugs can get to market in the shortest possible time. We have developed a partnering model to support this aim. It will progress research through to clinical trial quickly so that treatments can be brought to market and the threat from infectious diseases can be significantly reduced.
About iiCON
Decades of under-investment in new drugs and diagnostics means the world is ill-equipped to respond to the burgeoning challenge posed by infectious diseases, antibiotic resistance, and emerging pandemics. In response to this challenge, iiCON bridges the gap in the infection innovation ecosystem between industry, academia, and the NHS, to accelerate and support the discovery and development of innovative new anti-infectives.
iiCON’s collaborative effort is directly reducing the global burden of infectious disease with a co-ordinated initiative to address key roadblocks in global R&D pipelines and strengthen and regenerate the global anti-infectives supply chain.
The consortium is developing a leading global centre for infectious disease R&D in the North West of England as part of a £173.4 million programme. This capitalises on the region’s renowned track record in working on active translational programmes in vaccines, diagnostics, therapeutics and antiviral formulations. Led by founding Director, Professor Janet Hemingway CBE of LSTM, iiCON comprises six Academic, Industrial and NHS partners: LSTM, Liverpool University Hospitals NHS Foundation Trust, Unilever UK, the University of Liverpool, Infex Therapeutics and Evotec.
