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AMSBIO: Tailored Solutions for Exosome-related Research

Oxford, UK:  AMSBIO offers a comprehensive range of end-to-end services for exosome purification, characterization, and engineering. Exosomes are small endosome derived lipid nanoparticles, actively secreted by exocytosis in most living cells. Acting on tissues in both the local environment and further afield, they function as important signal carriers through their transport of RNA, proteins, lipids and DNA. Exosomes are involved in a wide range of normal and pathogenic processes, making exosome research crucial in multiple areas. Exosomes are a type of extracellular vesicle (EV) that show promise for use as unique drug carriers to deliver protease inhibitors to treat COVID-19. In this application, EVs may provide targeted delivery of protease inhibitors, with fewer systemic side effects. More importantly, EVs are highly suitable for major aseptic processing and can be upscaled for mass production. Currently, the FDA is backing applications to treat COVID-19, which provides a very good ...

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Encouraging Preclinical Results Generated with Sareum’s TYK2/JAK1 Inhibitors in a Disease Model of Lupus

Cambrdige, UK:  Sareum Holdings plc (AIM: SAR), the specialist drug development company delivering targeted small molecule therapeutics to improve the treatment of cancer and autoimmune diseases, is pleased to announce that encouraging results have been published for its small molecule dual tyrosine kinase 2 (TYK2) and Janus kinase 1 (JAK1) inhibitors in disease model studies of systemic lupus erythematosus (SLE) by its collaborator, SRI International. These studies were supported by a research grant from the US Department of Defense (DoD) and the report was recently published on the website of the Defense Technical Information Center (https://apps.dtic.mil/sti/citations/AD1087498). The authors concluded that an approach using selective TYK2/JAK1 inhibitors may lead to the development of a therapy for lupus that does not involve the harmful side effects of systemic immune system suppression and may benefit numerous lupus patients in need of new options. They also noted that the results could influe ...

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Leaf Expression Systems Appoints Dr. Leanne Williams as its Business Development Manager

Norwich, UK: Leaf Expression Systems (Leaf), a contract development and manufacturing organisation specialising in plant-based expression of proteins, vaccines, enzymes and complex natural products, is pleased to announce the recent appointment of Dr. Leanne Williams as Business Development Manager. Leanne has over 10 years’ experience working in the life sciences industry in both commercial and academic settings and will lead the growth of Leaf’s pipeline by identifying and establishing commercial collaborations within the global life science industry.

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Arcinova appoints new Non-Executive Director

Northumberland, UK:  Internationally renowned Industry veteran Steve Bagshaw joins Arcinova board to propel continued industry-leading growth Arcinova, one of the fastest growing multi-service Contract Development and Manufacturing Organisations (CDMOs), is delighted to welcome Steve Bagshaw to its board as a Non-Executive Director. Steve has almost two decades of board level experience, including leadership roles within Japanese, American and UK Private Equity corporate cultures. His proven acumen drove the rapid growth of a CDMO from $50m to over $600m turnover including transformational acquisitions both in Europe and the US.  Steve’s appointment continues Arcinova’s strategy of strengthening the company board following the appointment of Roger Kilburn as CEO in 2019. Steve’s contribution will be pivotal to the continued growth of the business over the next few years, underpinned by the company’s investor, Business Growth Fund (BGF), who are fully supportive of o ...

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AMR Action Fund | $1B USD generated

The AMR Action Fund totals approx. $1B USD and has been generated by 23 pharma companies in partnership with the WHO. This fund will focus on treatments for drug resistant infections, a major threat to global health and already responsible for 700,000 deaths per year.

Lloyd Payne PhD, Evotec' s EVP Head of Anti-Infectives Operations, discusses what this funding means for the future of AMR:

https://lnkd.in/dM4EVX5 | info@evotec.com #researchneverstops #AMR #antimicrobialresistance 

New England Biolabs’ SARS-CoV-2 Rapid Colorimetric LAMP Assay Kit Enables Visual Detection of Novel Coronavirus In 30 Minutes

The research use only kit can be used as a simple alternative to RT-qPCR for SARS-CoV-2 analysis.

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University of Birmingham spinout announces collaboration and licence agreement to develop precision cancer treatments

University of Birmingham spinout Revitope Oncology Inc has announced a research collaboration and licence agreement with leading Chinese biopharmaceutical company Junshi Biosciences to develop precision cancer therapies that harness the body’s immune response to kill cancer cells while leaving healthy body tissues untouched. Revitope will leverage its proprietary protein engineering platform with Junshi’s novel antibody components to develop first-in-class dual antigen targeting cancer therapies.   Revitope will receive up to $160 million per molecule in milestones and royalties on net sales of 10%.  Junshi has also committed to acquire a 9.99% stake in Revitope for $10 million. Revitope’s technology, known as the T-cell engager antibody circuit (TEAC), has the potential to significantly improve outcomes for millions of cancer patients.  The technology splits antibodies into two halves which are programmed to recognise different antigens.  The two halves ...

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Health Leadership in a Time of COVID: An interview with Asad Mohsin Ali, Director for UK and Ireland at Ipsen

In the last few months, almost every business has had to make some huge adjustments to how it operates. However, organisations in the healthcare sector have been thrust into the spotlight. They are not only having to ensure they maintain their critical services to patients and healthcare operators, but also are having to navigate a virus pandemic and look after their employees.

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Domainex Licenses Small Molecule Inhibitor for Treatment of Acute Myeloid Leukemia to Invivoscribe's New Division for Drug Development

    San Diego, California and Saffron Walden, UK:  Invivoscribe, Inc., an industry pioneer and global leader in the field of precision diagnostics announces the launch of a fully integrated drug development engine. This new engine will combine with its in-house expertise in diagnostics development and worldwide access to patients and clinical testing capabilities to accelerate drug development.   Invivoscribe’s therapeutics division also announced today that the company has in-licensed technology involving a preclinical molecule and associated small molecules from Domainex Ltd. Domainex is a rapidly growing, well established integrated drug discovery service company in the UK that has utilized its novel, proprietary technologies to develop a first-in-class small molecule program against a difficult to target enzyme. Under the license agreement, Invivoscribe will develop and commercialize certain molecules generated by Domainex as oral immunotherapy agents to treat hem ...

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Innovate UK launches the next round of the Biomedical Catalyst - launch on 27th July

£30 Million is available to support industry-led research and development projects that seek to provide solutions to Health and Care challenges.

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