GyreOx Ltd is a young and vibrant company with headquarters on the Harwell Research Campus in Oxfordshire, UK.  The Company has developed a proprietary combined chemistry and synthetic biology technology for the creation of highly modified macrocyclic peptides, which have the potential to address complex intracellular targets in a range of diseases of significant unmet clinical need.

We are currently recruiting for two positions, see https://www/

Synthetic Chemist (GT-2020-1)

A PhD-level scientist is sought to work on the Company’s automated platform and new drug development programmes.  This will be predominantly laboratory-based in the first instance.  It is initially part-funded by a grant from Innovate UK, but represents the potential for a future leadership role within the Company, through developing an understanding of the commercial aspects of the Company’s business.

In this position, your responsibilities will include: the synthesis and purification of libraries of linear and cyclic peptide-based compounds, using both automated peptide synthesisers and manual procedures; cleavage of peptides from resin supports; analysis by HPLC and mass spectrometry; and, modifications of peptides by enzymatic biotransformation.

Practical experience in peptide synthesis, organic synthesis or solid-phase synthesis is essential.

Experience of using automated peptide synthesisers and manual procedures for peptide synthesis, previous experience in industry/academia, with exposure to technology transfer and production support would be desirable.

A PhD in an appropriate chemical or biochemical subject would be expected, but consideration will be given to applicants who have acquired the necessary experience within industry, particularly within drug discovery.  Knowledge of the synthesis, purification, analysis and development of peptides and macrocycles would be advantageous, but is not essential.